Derek Sim


Website:
Email: dgs15@psu.edu

C.V.

JOBS:
Pennsylvania State University, USA (2007-current)
Senior Research Assistant

Assistant Research Professor (2017)

University of Edinburgh, Scotland (2003-2007)
Senior Research Technician

Institute for Animal Health, Berkshire, England. (2000-2003)
Research Technician

University of Bath, England. (1999-2000)
Pharmacology Technician

DEGREES:
B.Sc (Hons) Microbiology, Glasgow Caledonian University, Scotland. (1995-1999).
M.Sc Medical Molecular biology, Westminster University, London, England. (2001-2003).

Research interests


Publications

Wale, N., Sim, D.G., Jones, M.J., Salathe, R., Day, T., & Read, A.F. (in press). Resource limitation prevents the emergence of drug resistance by intensifying within host competition. Proceedings of the National Academy of Science USA 

Liu, J., Cattadori, I., Sim, D.G., Eden, J-S. Holmes, E.C., Read, A.F., & Kerr, P.J. (in press). Reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or loss of function do not explain virulence changes observed in the field. Journal of Virology. 

Kerr. P.J., Cattadori, I., Liu, J., Sim, D.G., Dodds, J., Brooks, J., Kennett, M., Holmes, E.C., & Read, A.F. (2017). The next step in the on-going arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype. Proceedings of the National Academy of Science USA.

Wale, N., Sim, D.G., & Read, A.F. (2017). A nutrient mediates intraspecific competition between rodent malaria parasites in vivo. Proceedings of the Royal Society of London Series B 284: 20171067

Kerr, P.J., Cattadori, I., Rogers, M.B., Fitch, A., Geber, A., Liu, J., Sim, D.G., Boag, B., Eden, J-B., Ghedin, E., Read, A.F., & Holmes, E.C. (2017). Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia. PLoS Pathogens 13: e1006252.

Ssentongo, P., Robuccio, A.E., Thuku, G., Sim, D.G., Nabi, A., Bahari, F., Shanmugasundaram, B., Billard, M., Geronimo, A., Short, K.W., Drew, P.J., Baccon, J., Weinstein, S.L., Gilliam, F.G., Soute, J.A., Chincilli, V., Read, A.F., Gluckman, B.J., & Schiff, S.J. (2017). A murine model to study epilepsy and SUDEP induced by malaria infection. Scientific Reports 7:43652.

Moraes, C.M., Stanczyk, N.M., Betz, H.S., Sim, D.G., Read, A.F. & Mescher, M.C. (2014). Scent of disease: Malaria-induced changes in host odors enhance mosquito attraction. Proceedings of the National Academy of Science USA

Pollitt, L.C., Sim, D.G., Salathe, R.M., & Read, A.F. (2014). Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring. Evolutionary Applications.

Pollitt, L.C., Huijben, S., Sim, D.G., Salathe, R.M., Jones, M. & Read, A.F. (2014). Rapid response to selection, competitive release and increased transmission potential of artesunate-selected Plasmodium chabaudimalaria parasites. PLoS Pathogens

Barclay, V.C., Kennedy, D., Weaver, V.C., Sim, D., Lloyd-Smith, J.O. & Read, A.F. (2014). The effect of immunodeficiency on the evolution of virulence: an experimental test with the rodent malaria Plasmodium chabaudiAmerican Naturalist

Huijben, S., Bell, A. S., Sim, D.., Salathe, R., Tomasello, D., Mideo, N., Day, T., & Read, A.F. (2013). Aggressive chemotherapy and the selection of drug resistant pathogens. PLoS Pathogens 9: e1003578.

Schneider, P., Bell, A.S., Sim, D.., O’Donnell, A.J., Blanford, S., Paaijmans, K.P., Read, A.F., & Reece, S.E. (2012). Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudiProceedings of the Royal Society of London Series B. PDF

Barclay, V.C., Sim, D., Chan, B.H.K., Nell, L.A., Rabaa, M.A., Bell, A.S., Anders, R.F., Read, A.F. (2012).  The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi. PLoS Biology 10: e1001368.

Bell, A.S, Huijben, S., Paaijmans, K.P., Sim, D., Chan, B.H.K., Nelson, W.A., & Read A.F. (2012). Enhanced transmission of drug-resistance parasites to mosquitoes following drug treatment in rodent malaria. PLoS One.

Huijben, S., Sim, D., Nelson, W.A., & Read, A.F. (2011), The fitness of drug resistant malaria parasites in a rodent model: multiplicity of infection. Journal of Evolutionary Biology 24: 2410-2422 doi: 10.1111/j.1420-9101.2011.02369.x

Huijben, S., Nelson, W.A., Wargo, A.R., Sim, D., Drew, D.R., & Read, A.F. (2010). Chemotherapy, within-host ecology and the fitness of drug resistant malaria parasites. Evolution. DOI: 10.1111/j.1558-5646.2010.01068.x

Råberg, L., Sim, D. & Read, A.F.(2007) Disentangling genetic variation for resistance and tolerance to infectious diseases in animals. Science.318: 812

Bell, A.S., de Roode, C.J., Sim, D. & Read, A. F. (2006) . Within-host competition in genetically diverse malaria infections: parasite virulence and competitive success. Evolution. 60 (7):1358-1371.

Blanford, S., Chan, B.H.K., Jenkins, N., Sim, D., Turner, R.J., Read, A.F., & Thomas, M.B. (2005) Fungal pathogen reduces potential for malaria transmission. Science. 308: 1638-1641.

 

Miscellaneous

I enjoy sailing, windsurfing and fatherhood.