One of the worst things about being an Academic Editor for journals is trying to decide if something is sufficiently interesting to send it to review. It’s so subjective. One reason I dislike it so much is my experience on the receiving end of these calls, not least the following. They concern our 2015 paper, Imperfect vaccination can enhance the transmission of highly virulent pathogens.
Science: “The overall view is that while your paper will be of great interest to the field it is not one of the most competitive in terms of general interest.”
Nature: “[W]e do not believe that it represents a development of sufficient scientific impact to warrant publication in Nature.”
PLoS Biology:
Rev 1: “The findings are important, not only for the field of MDV research, but also for the field of vaccine research in general.”
Rev 2: “This is an important topic and should be of broad interest.”
Rev 3: “[T]his work has broad significance to all of disease evolution, and the results are unassailable.”
Rev 4: “It’s an important paper that should be published.”